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Article

PBRM1 loss is a late event during the development of cholangiocarcinoma.

Histopathology - 1 Sept 2017

Luchini Claudio, Robertson Scott A, Hong Seung-Mo, Felsenstein Matthäus, Anders Robert A, Pea Antonio, Nottegar Alessia, Veronese Nicola, He Jin, Weiss Matthew J, Capelli Paola, Scarpa Aldo, Argani Pedram, Kapur Payal, Wood Laura D

Abstract excerpt

AIMS: Somatic mutations in genes encoding chromatin remodellers have been reported recently in several cancer types, including approximately half of cholangiocarcinomas. One of the most commonly mutated chromatin remodellers in cholangiocarcinoma is the Polybromo-1 (PBRM1) gene located on chromosome 3p21, which encodes a subunit of the SWI/SNF complex. The aim of this study was to determine the timing of PBRM1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28394406
DOI: 10.1111/his.13234
PMCID: PMC5552448

Genes

PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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