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Article

Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

PloS one - 1 Jan 2013

Wang Yan, Hong Yu, Li Man, Long Jiang, Zhao Yan-Ping, Zhang Jun-Xia, Li Qian, You Hong, Tong Wei-Min, Jia Ji-Dong, Huang Jian

Abstract excerpt

Nijmegen breakage syndrome (NBS) with NBS1 germ-line mutation is a human autosomal recessive disease characterized by genomic instability and enhanced cancer predisposition. The NBS1 gene codes for a protein, Nbs1(p95/Nibrin), involved in the processing/repair of DNA double-strand breaks. Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with several genomic alterations. Recent studies have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24349281
DOI: 10.1371/journal.pone.0082426
PMCID: PMC3862623

Genes

MDM2

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