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Article

Nuclear BAP1 loss is common in intrahepatic cholangiocarcinoma and a subtype of hepatocellular carcinoma but rare in pancreatic ductal adenocarcinoma.

Cancer genetics - 1 Aug 2018

Mosbeh Asmaa, Halfawy Khalil, Abdel-Mageed Wael S, Sweed Dina, Rahman Mohamed H Abdel

Abstract excerpt

Deletion in the 3p21 region, the chromosomal location of BAP1, has been reported in a subset of hepatocellular carcinoma (HCC), biliary and pancreatic cancers. This suggests that BAP1 could play a role in the pathogenesis of these tumors. We assessed the frequency of BAP1 loss by immunohistochemistry in 103 hepatic, biliary and pancreatic cancers. We also assessed chromosomal alterations in the BAP1 region in the...

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Carcinoma, Hepatocellular
Carcinoma, Pancreatic Ductal
Cholangiocarcinoma
Genotype
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Tumor Suppressor Proteins

Ubiquitin Thiolesterase

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Open in PubMed Open full text

Identifiers

PMID: 29778232
DOI: 10.1016/j.cancergen.2018.03.002
PMCID: PMC5996975

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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