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Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.

Bioorganic & medicinal chemistry - 1 May 2011

Su Jing, Wang Qiang, Feng Jinhong, Zhang Cong, Zhu Deyu, Wei Tiandi, Xu Wenfang, Gu Lichuan

Abstract excerpt

Human aminopeptidase N (hAPN) is an appealing objective for the development of anti-cancer agents. The absence of mammalian APN experimental structure negatively impinges upon the progression of structure-based drug design. Tricorn interacting factor F3 (factor F3) from Thermoplasma acidophilum shares 33% sequence identity with hAPN. Engineered factor F3 with two point directed mutations resulted in a protein...

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PMID: 21493078
DOI: 10.1016/j.bmc.2011.03.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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