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Article

p53 Arg72Pro polymorphism, HPV status and initiation, progression, and development of cervical cancer: a systematic review and meta-analysis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2012

Habbous Steven, Pang Vincent, Eng Lawson, Xu Wei, Kurtz Goldie, Liu Fei-Fei, Mackay Helen, Amir Eitan, Liu Geoffrey

Abstract excerpt

Cervical cancer develops through progression from normal cervical epithelium through squamous intraepithelial lesions (SIL) to invasive cancer. Cervical cancer is associated with oncogenic human papillomavirus (HPV). The HPV E6 oncoprotein binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of p53 Arg72Pro polymorphism binds more ardently with HPV E6 than the Pro variant....

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PMID: 23065429
DOI: 10.1158/1078-0432.CCR-12-1983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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