Article
p53 Arg72Pro polymorphism, HPV status and initiation, progression, and development of cervical cancer: a systematic review and meta-analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2012
Habbous Steven, Pang Vincent, Eng Lawson, Xu Wei, Kurtz Goldie, Liu Fei-Fei, Mackay Helen, Amir Eitan, Liu Geoffrey
Abstract excerpt
Cervical cancer develops through progression from normal cervical epithelium through squamous intraepithelial lesions (SIL) to invasive cancer. Cervical cancer is associated with oncogenic human papillomavirus (HPV). The HPV E6 oncoprotein binds to the tumor suppressor gene product p53, promoting...
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