Article
p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population.
Cancer letters - 1 Jan 2010
Ye Feng, Zhang Jing, Cheng Qi, Shen Jiajie, Chen Huaizeng
Abstract excerpt
We investigated the genotype distribution of the p53 Arg72Pro polymorphisms in 500 cervical carcinoma and 800 normal women in Chinese population. HPV infection rates in carcinoma patients and control were 89.4% and 31.0%. Women carrying the p53 Arg72Pro or p53 Pro72Pro increased the risk of cervical carcinoma (ORs and 95% CIs being 3.74 (2.65-5.30), 2.23 (1.49-3.34)). In HPV positive population, elevated risks...
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