Article
De novo RNA sequence assembly during in vivo inflammatory stress reveals hundreds of unannotated lincRNAs in human blood CD14+ monocytes and in adipose tissue.
Physiological genomics - 1 Jun 2017
Xue Chenyi, Zhang Xuan, Zhang Hanrui, Ferguson Jane F, Wang Ying, Hinkle Christine C, Li Mingyao, Reilly Muredach P
Abstract excerpt
Long intergenic noncoding RNAs (lincRNAs) have emerged as key regulators of cellular functions and physiology. Yet functional lincRNAs often have low, context-specific and tissue-specific expression. We hypothesized that many human monocyte and adipose lincRNAs would be absent in current public annotations due to lincRNA tissue specificity, modest sequencing depth in public data, limitations of transcriptome...
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