Article
Nonconserved Long Intergenic Noncoding RNAs Associate With Complex Cardiometabolic Disease Traits.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2021
Foulkes Andrea S, Selvaggi Caitlin, Cao Tingyi, O'Reilly Marcella E, Cynn Esther, Ma Puyang, Lumish Heidi, Xue Chenyi, Reilly Muredach P
Abstract excerpt
OBJECTIVE: Transcriptome profiling of human tissues has revealed thousands of long intergenic noncoding RNAs (lincRNAs) at loci identified through large-scale genome-wide studies for complex cardiometabolic traits. This raises the question of whether genetic variation at nonconserved lincRNAs has any systematic association with complex disease, and if so, how different this pattern is from conserved lincRNAs. We...
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