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Article

Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients.

PloS one - 1 Jan 2011

Yimer Getnet, Ueda Nobuhisa, Habtewold Abiy, Amogne Wondwossen, Suda Akira, Riedel Klaus-Dieter, Burhenne Jürgen, Aderaye Getachew, Lindquist Lars, Makonnen Eyasu, Aklillu Eleni

Abstract excerpt

BACKGROUND: Implication of pharmacogenetic variations and efavirenz pharmacokinetics in concomitant efavirenz based antiviral therapy and anti-tubercular drug induced liver injury (DILI) has not been yet studied. We performed a prospective case-control association study to identify the incidence, pharmacogenetic, pharmacokinetic and biochemical predictors for anti-tubercular and antiretroviral drugs induced liver...

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Source

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Identifiers

PMID: 22162992
DOI: 10.1371/journal.pone.0027810
PMCID: PMC3232196

Genes

ABCB1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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