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Article

BDNF-Dependent Effects on Amygdala-Cortical Circuitry and Depression Risk in Children and Youth.

Cerebral cortex (New York, N.Y. : 1991) - 1 May 2018

Wheeler Anne L, Felsky Daniel, Viviano Joseph D, Stojanovski Sonja, Ameis Stephanie H, Szatmari Peter, Lerch Jason P, Chakravarty M Mallar, Voineskos Aristotle N

Abstract excerpt

The brain-derived neurotrophic factor (BDNF) is critical for brain development, and the functional BDNF Val66Met polymorphism is implicated in risk for mood disorders. The objective of this study was to determine how the Val66Met polymorphism influences amygdala-cortical connectivity during neurodevelopment and assess the relevance for mood disorders. Age- and sex-specific effects of the BDNF Val66Met...

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Source

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Identifiers

PMID: 28387866
DOI: 10.1093/cercor/bhx086
PMCID: PMC5907350

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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