Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes.

doi:10.1017/S0954579414001357

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Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes.

Development and psychopathology - 1 Feb 2015

Chen Li, Pan Hong, Tuan Ta Anh, Teh Ai Ling, MacIsaac Julia L, Mah Sarah M, McEwen Lisa M, Li Yue, Chen Helen, Broekman Birit F P, Buschdorf Jan Paul, Chong Yap Seng, Kwek Kenneth, Saw Seang Mei, Gluckman Peter D, Fortier Marielle V, Rifkin-Graboi Anne, Kobor Michael S, Qiu Anqi, Meaney Michael J, Holbrook Joanna D

Abstract excerpt

Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA...

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PMID: 25640836
DOI: 10.1017/S0954579414001357

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BDNF

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