Article

Elevated FGF21 and triglycerides in <i>SLC25A13</i> carriers support the G3P-ChREBP Citrin Deficiency disease hypothesis: A cross-sectional biobank study

2025-12-12

Abstract excerpt

<h4>Introduction</h4> People with Citrin Deficiency (CD), inactivated for both copies of SLC25A13 , have lean metabolic dysfunction-associated steatotic liver disease (MASLD) and an aversion to sweets. The mouse model of CD, which inactivates Slc25a13 and Gpd2 , has been shown to elevate hepatic glycerol-3-phosphate (G3P) and activate carbohydrate response element binding protein (ChREBP) thereby increasing li...

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Literature Corpus work: e66b9f68-68c9-528a-a76c-c7c5fa4c8476
DOI: 10.64898/2025.12.10.25342016

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