Article
A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure.
Cell reports - 10 Apr 2018
Frayling Timothy M, Beaumont Robin N, Jones Samuel E, Yaghootkar Hanieh, Tuke Marcus A, Ruth Katherine S, Casanova Francesco, West Ben, Locke Jonathan, Sharp Seth, Ji Yingjie, Thompson William, Harrison Jamie, Etheridge Amy S, Gallins Paul J, Jima Dereje, Wright Fred, Zhou Yihui, Innocenti Federico, Lindgren Cecilia M, Grarup Niels, Murray Anna, Freathy Rachel M, Weedon Michael N, Tyrrell Jessica, Wood Andrew R
Abstract excerpt
Fibroblast growth factor 21 (FGF21) is a hormone that has insulin-sensitizing properties. Some trials of FGF21 analogs show weight loss and lipid-lowering effects. Recent studies have shown that a common allele in the FGF21 gene alters the balance of macronutrients consumed, but there was little evidence of an effect on metabolic traits. We studied a common FGF21 allele (A:rs838133) in 451,099 people from the UK...
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