Article
The PD-1 expressing immune phenotype of T cell exhaustion is prominent in the 'immunoreactive' microenvironment of colorectal carcinoma.
Histopathology - 1 Sept 2017
Prall Friedrich, Hühns Maja
Abstract excerpt
AIMS: This study was designed to test programmed cell death 1 (PD-1) expression of T cells, the hallmark of T cell exhaustion, in different 'immune-classes' of colorectal carcinoma microenvironments as delineated by unsupervised hierarchical cluster analysis. METHODS AND RESULTS: A tissue microarray was made with punches from the invasive margins of 40 microsatellite-unstable and 34 microsatellite-stable...
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