Article
Selective targeting of gain-of-function KCNQ1 mutations predisposing to atrial fibrillation.
Circulation. Arrhythmia and electrophysiology - 1 Oct 2013
Campbell Courtney M, Campbell Jonathan D, Thompson Christopher H, Galimberti Eleonora Savio, Darbar Dawood, Vanoye Carlos G, George Alfred L
Abstract excerpt
BACKGROUND: Atrial fibrillation is the most common sustained cardiac arrhythmia in adults. We hypothesized that gain-of-function KCNQ1 mutations previously associated with familial atrial fibrillation have distinct pharmacological properties that may enable targeted inhibition. METHODS AND RESULTS: Wild-type (WT) KCNQ1 or the familial atrial fibrillation mutation KCNQ1-S140G was heterologously coexpressed with...
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