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Article

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

17 Sept 2020

Abstract excerpt

The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for the treatment of several viral diseases. We demonstrate here that Favipiravir predominantly exerts an...

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PMID: 32943628
DOI: 10.1038/s41467-020-18463-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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