Article
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.
Blood - 18 May 2017
Man Na, Tan Yurong, Sun Xiao-Jian, Liu Fan, Cheng Guoyan, Greenblatt Sarah M, Martinez Camilo, Karl Daniel L, Ando Koji, Sun Ming, Hou Dan, Chen Bingyi, Xu Mingjiang, Yang Feng-Chun, Chen Zhu, Chen Saijuan, Nimer Stephen D, Wang Lan
Abstract excerpt
AML1-ETO (AE), a fusion oncoprotein generated by t(8;21), can trigger acute myeloid leukemia (AML) in collaboration with mutations including c-Kit, ASXL1/2, FLT3, N-RAS, and K-RAS. Caspase-3, a key executor among its family, plays multiple roles in cellular processes, including hematopoietic development and leukemia progression. Caspase-3 was revealed to directly cleave AE in vitro, suggesting that AE may...
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