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Article

Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.

Journal of the American College of Cardiology - 7 Aug 2012

Parvez Babar, Vaglio Joseph, Rowan Shane, Muhammad Raafia, Kucera Gayle, Stubblefield Tanya, Carter Shannon, Roden Dan, Darbar Dawood

Abstract excerpt

OBJECTIVES: This study tested the hypothesis that response to antiarrhythmic drugs (AADs) is modulated by 3 common loci associated with atrial fibrillation (AF). BACKGROUND: Recent genome-wide association studies have identified 3 loci, on chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), that associate with either typical or lone AF. These findings indicate that variable mechanisms contribute...

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Identifiers

PMID: 22726630
DOI: 10.1016/j.jacc.2012.01.070
PMCID: PMC3411889

Genes

KCNN3
PITX2
ZFHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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