Article
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Nature genetics - 1 Aug 2009
Benjamin Emelia J, Rice Kenneth M, Arking Dan E, Pfeufer Arne, van Noord Charlotte, Smith Albert V, Schnabel Renate B, Bis Joshua C, Boerwinkle Eric, Sinner Moritz F, Dehghan Abbas, Lubitz Steven A, D'Agostino Ralph B, Lumley Thomas, Ehret Georg B, Heeringa Jan, Aspelund Thor, Newton-Cheh Christopher, Larson Martin G, Marciante Kristin D, Soliman Elsayed Z, Rivadeneira Fernando, Wang Thomas J, Eiríksdottir Gudny, Levy Daniel, Psaty Bruce M, Li Man, Chamberlain Alanna M, Hofman Albert, Vasan Ramachandran S, Harris Tamara B, Rotter Jerome I, Kao W H Linda, Agarwal Sunil K, Stricker Bruno H Ch, Wang Ke, Launer Lenore J, Smith Nicholas L, Chakravarti Aravinda, Uitterlinden André G, Wolf Philip A, Sotoodehnia Nona, Köttgen Anna, van Duijn Cornelia M, Meitinger Thomas, Mueller Martina, Perz Siegfried, Steinbeck Gerhard, Wichmann H-Erich, Lunetta Kathryn L, Heckbert Susan R, Gudnason Vilmundur, Alonso Alvaro, Kääb Stefan, Ellinor Patrick T, Witteman Jacqueline C M
Abstract excerpt
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network...
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