Article
Interaction Dynamics Determine Signaling and Output Pathway Responses.
Cell reports - 4 Apr 2017
Stojanovski Klement, Ferrar Tony, Benisty Hannah, Uschner Friedemann, Delgado Javier, Jimenez Javier, Solé Carme, de Nadal Eulalia, Klipp Edda, Posas Francesc, Serrano Luis, Kiel Christina
Abstract excerpt
The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key upstream osmosensor in the yeast high-osmolarity glycerol-mitogen-activated protein kinase (HOG-MAPK) pathway to signaling output responses. We created mutant pairs of the Sln1-Ypd1 complex...
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