Article
Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50.
The Journal of biological chemistry - 5 Dec 2008
Hao Nan, Zeng Yaxue, Elston Timothy C, Dohlman Henrik G
Abstract excerpt
Many different signaling pathways share common components but nevertheless invoke distinct physiological responses. In yeast, the adaptor protein Ste50 functions in multiple mitogen-activated protein (MAP) kinase pathways, each with unique dynamical and developmental properties. Although Kss1 activity is sustained and promotes invasive growth, Hog1 activity is transient and promotes cell adaptation to osmotic...
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