Article
Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast.
Molecular systems biology - 1 Jan 2012
Schaber Jörg, Baltanas Rodrigo, Bush Alan, Klipp Edda, Colman-Lerner Alejandro
Abstract excerpt
The high osmolarity glycerol (HOG) pathway in yeast serves as a prototype signalling system for eukaryotes. We used an unprecedented amount of data to parameterise 192 models capturing different hypotheses about molecular mechanisms underlying osmo-adaptation and selected a best approximating mod...
Topics
- Adaptation, Physiological
- Chromosomal Proteins, Non-Histone
- Computer Simulation
- DNA-Binding Proteins
- Feedback, Physiological
- Glycerol
- Homeostasis
- Intracellular Space
- Mitogen-Activated Protein Kinases
- Models, Biological
- Mutation
- Osmotic Pressure
- Phosphorylation
- Saccharomyces cerevisiae