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Article

Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast.

Molecular systems biology - 1 Jan 2012

Schaber Jörg, Baltanas Rodrigo, Bush Alan, Klipp Edda, Colman-Lerner Alejandro

Abstract excerpt

The high osmolarity glycerol (HOG) pathway in yeast serves as a prototype signalling system for eukaryotes. We used an unprecedented amount of data to parameterise 192 models capturing different hypotheses about molecular mechanisms underlying osmo-adaptation and selected a best approximating model. This model implied novel mechanisms regulating osmo-adaptation in yeast. The model suggested that (i) the main...

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Identifiers

PMID: 23149687
DOI: 10.1038/msb.2012.53
PMCID: PMC3531907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast.PMID 23149687Read ↗

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