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Article

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia.

Leukemia - 1 Nov 2020

Kloos Arnold, Mintzas Konstantinos, Winckler Lina, Gabdoulline Razif, Alwie Yasmine, Jyotsana Nidhi, Kattre Nadine, Schottmann Renate, Scherr Michaela, Gupta Charu, Adams Felix F, Schwarzer Adrian, Heckl Dirk, Schambach Axel, Imren Suzan, Humphries R Keith, Ganser Arnold, Thol Felicitas, Heuser Michael

Abstract excerpt

To establish novel and effective treatment combinations for chronic myelomonocytic leukemia (CMML) preclinically, we hypothesized that supplementation of CMML cells with the human oncogene Meningioma 1 (MN1) promotes expansion and serial transplantability in mice, while maintaining the functional dependencies of these cells on their original genetic profile. Using lentiviral expression of MN1 for oncogenic...

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Identifiers

PMID: 32576961
DOI: 10.1038/s41375-020-0929-3
PMCID: PMC7116758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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