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Article

Clinical Significance of DNA Damage Response Factors and Chromosomal Instability in Primary Lung Adenocarcinoma.

Anticancer research - 1 Apr 2017

Okamoto Tatsuro, Kohno Mikihiro, Ito Kensaku, Takada Kazuki, Katsura Masakazu, Morodomi Yosuke, Toyokawa Gouji, Shoji Fumihiro, Maehara Yoshihiko

Abstract excerpt

AIM: The purpose of this study was to investigate the biological role of DNA damage-response genes and chromosomal instability in primary lung adenocarcinoma. MATERIALS AND METHODS: We investigated 60 surgically-resected lung adenocarcinomas. Levels of checkpoint kinase 2 gene (CHEK2) and breast cancer type 1 susceptibility protein gene (BRCA1) mRNA expression were evaluated by polymerase chain reaction (PCR)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28373435
DOI: 10.21873/anticanres.11505

Genes

CHEK2
BRCA1
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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