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Article

Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer

13 May 2016

Abstract excerpt

BACKGROUND: BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate the function of BRCA1. The E3 ubiquitin ligase HERC2 facilitates the assembly of the RNF8-UBC13 complex to recruit BRCA1 to DNA damage sites. The combined analysis of multiple components of the...

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PMID: 27179511
DOI: 10.1186/s12885-016-2339-5

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