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Article

Opposite roles of FOXA1 and NKX2‐1 in lung cancer progression

2 Mar 2012

Abstract excerpt

Gene copy number profiles of primary lung tumors were screened for high-level amplifications. We detected 22 high-level amplifications in various loci, including 14q13. This locus is known to harbor the adenocarcinoma (AC) lineage-specific target gene NKX2-1, which is not expressed in squamous cell carcinoma (SCC). As the 14q amplification was also found in SCC, we investigated whether or not FOXA1 might be the...

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PMID: 22383183
DOI: 10.1002/gcc.21950

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