Article
Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.
Journal of pineal research - 1 Aug 2017
Rahim Ibtissem, Djerdjouri Bahia, Sayed Ramy K, Fernández-Ortiz Marisol, Fernández-Gil Beatriz, Hidalgo-Gutiérrez Agustín, López Luis C, Escames Germaine, Reiter Russel J, Acuña-Castroviejo Darío
Abstract excerpt
The NLRP3 inflammasome is involved in the innate immune response during inflammation. Moreover, melatonin blunts the NF-κB/NLRP3 connection during sepsis. Thus, we compared the roles of the NLRP3 inflammasome and/or melatonin treatment in the septic response of wild-type and NLRP3-/- mice. Mouse myocardial tissue was used for this purpose. The nuclear turnover of NF-κB was enhanced during sepsis, with an increase...
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