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Article

Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Zhang Zhirong, Xu Xiaozheng, Ma Jianhui, Wu Jianfeng, Wang Yanhai, Zhou Rongbin, Han Jiahuai

Abstract excerpt

The γ-aminobutyric acid A receptor-associated protein (Gabarap) functions in γ-aminobutyric acid A receptor trafficking and postsynaptic localization in neurons, but its physiological roles in other systems have not been studied. In this study, we report that Gabarap-deficient mice are more susceptible to mortality in two sepsis models. An underlying mechanism of this higher mortality rate in Gabarap(-/-) septic...

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Identifiers

PMID: 23427251
DOI: 10.4049/jimmunol.1202628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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