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Article

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.

Molecular human reproduction - 1 Jun 2017

Nguyen Alexandra L, Marin Diego, Zhou Anbo, Gentilello Amanda S, Smoak Evan M, Cao Zubing, Fedick Anastasia, Wang Yujue, Taylor Deanne, Scott Richard T, Xing Jinchuan, Treff Nathan, Schindler Karen

Abstract excerpt

STUDY QUESTION: Are single nucleotide variants (SNVs) in Aurora kinases B and C (AURKB, AURKC) associated with risk of aneuploid conception? SUMMARY ANSWER: Two SNVs were found in patients with extreme aneuploid concepti rates with respect to their age; one variant, AURKC p.I79V, is benign, while another, AURKB p.L39P, is a potential gain-of-function mutant with increased efficiency in promoting chromosome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28369513
DOI: 10.1093/molehr/gax018
PMCID: PMC9915067

Genes

AURKB
AURKC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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