Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation screening of AURKB and SYCP3 in patients with reproductive problems.

Molecular human reproduction - 1 Feb 2013

López-Carrasco A, Oltra S, Monfort S, Mayo S, Roselló M, Martínez F, Orellana C

Abstract excerpt

Mutations in the spindle checkpoint genes can cause improper chromosome segregations and aneuploidies, which in turn may lead to reproductive problems. Two of the proteins involved in this checkpoint are Aurora kinase B (AURKB), preventing the anaphase whenever microtubule-kinetochore attachments are not the proper ones during metaphase; and synaptonemal complex protein 3 (SYCP3), which is essential for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase B
Share to Aurora Kinases
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

Share to Nuclear Proteins

Share to Pregnancy

Share to Protein Serine-Threonine Kinases

Share to Reproduction

Source

Identifiers

PMID: 23100464
DOI: 10.1093/molehr/gas047

Genes

AURKB
SYCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation screening of AURKB and SYCP3 in patients with reproductive problems.PMID 23100464Read ↗

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.Semantic proximity Read ↗

Analysis of SYCP3 encoding synaptonemal complex protein 3 in human aneuploidies.Semantic proximity Read ↗

[Function of aurora kinase C (AURKC) in human reproduction].Semantic proximity Read ↗

Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system.Semantic proximity Read ↗

The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population.Semantic proximity Read ↗

Mutations of the SYCP3 gene in women with recurrent pregnancy loss.Semantic proximity Read ↗

Successful intracytoplasmic sperm injection in a macrozoospermia case with novel compound heterozygous aurora kinase C (AURKC) mutations.Semantic proximity Read ↗

Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteinsSemantic proximity Read ↗

Aurora kinases link chromosome segregation and cell division to cancer susceptibility.Semantic proximity Read ↗

The T657C polymorphism on the SYCP3 gene is associated with recurrent pregnancy loss.Semantic proximity Read ↗

Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest.Semantic proximity Read ↗

Mutations in Genes Coding for Synaptonemal Complex Proteins and Their Impact on Human Fertility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.