Article
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes
24 Oct 2023
Abstract excerpt
Aneuploidy seriously compromises female fertility and increases incidence of birth defects. Rates of aneuploidy in human eggs from even young women are significantly higher than those in other mammals. However, intrinsic genetic factors underlying this high incidence of aneuploidy in human eggs remain largely unknown. Here, we found that ectopic expression of human TUBB8 in mouse oocytes increases rates of...
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