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Article

Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy.

Proceedings of the National Academy of Sciences of the United States of America - 5 Nov 2024

Biswas Leelabati, Tyc Katarzyna M, Aboelenain Mansour, Sun Siqi, Dundović Iva, Vukušić Kruno, Liu Jason, Guo Vanessa, Xu Min, Scott Richard T, Tao Xin, Tolić Iva M, Xing Jinchuan, Schindler Karen

Abstract excerpt

The female reproductive lifespan is highly dependent on egg quality, especially the presence of a normal number of chromosomes in an egg, known as euploidy. Mistakes in meiosis leading to egg aneuploidy are frequent in humans. Yet, knowledge of the precise genetic landscape that causes egg aneuploidy in women is limited, as phenotypic data on the frequency of human egg aneuploidy are difficult to obtain and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39475646
DOI: 10.1073/pnas.2414963121
PMCID: PMC11551467

Genes

KIF18A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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