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Article

MAD1L1 and MAD2L1 genes variants in spontaneous miscarriage with aneuploidy.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 3 Aug 2026

Hosseini Narges, Kariminejad Roxana, Boroujeni Parnaz Borjian, Amiri-Yekta Amir, Bazrgar Masood

Abstract excerpt

Aneuploidy accounts for over 57% of spontaneous abortions and occurs even in women of young reproductive age. Despite its major role in pregnancy loss, the genetic basis of fetal aneuploidy remains poorly characterized. This study evaluated the association of MAD1L1 and MAD2L1, two key spindle assembly checkpoint genes, with fetal aneuploidy in women younger than 36 years. Forty aborted fetuses with approved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42545408
DOI: 10.1007/s10577-026-09810-9

Genes

MAD1L1
MAD2L1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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