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Article

Mutational analysis and a structural model of methyl-directed restriction enzyme Mrr.

Biochemical and biophysical research communications - 19 Dec 2008

Orlowski Jerzy, Mebrhatu Mehari Tesfazgi, Michiels Chris W, Bujnicki Janusz M, Aertsen Abram

Abstract excerpt

The Mrr protein of Escherichia coli K12 is a cryptic Type IV restriction endonuclease whose activity appears to be triggered by high pressure stress. In this report we used high pressure to isolate and analyze several Mrr mutants, and generated a new structural model of the Mrr protein. The activity of a number of spontaneous and strategically constructed Mrr mutants is discussed in the light of this model,...

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Source

Identifiers

PMID: 18951880
DOI: 10.1016/j.bbrc.2008.10.064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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