Article
Construction and characterization of a mercury-independent MerR activator (MerRAC): transcriptional activation in the absence of Hg(II) is accompanied by DNA distortion.
The EMBO journal - 1 Feb 1993
Parkhill J, Ansari A Z, Wright J G, Brown N L, O'Halloran T V
Abstract excerpt
The MeR regulatory protein of transposon Tn501 controls the expression of the mercury resistance (mer) genes in response to the concentration of mercuric ions. MerR is unique among prokaryotic regulatory proteins so far described in that it acts as a repressor [-Hg(II)] and an activator [+Hg(II)]...
Topics
- Allosteric Regulation
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- DNA
- DNA-Binding Proteins
- Mercury
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Promoter Regions, Genetic
- Protein Binding
- Transcription Factors
- Transcription, Genetic