Article
Possible Interaction Between Cigarette Smoking and HLA-DRB1 Variation in the Risk of Follicular Lymphoma.
American journal of epidemiology - 15 Apr 2017
Baecklund Fredrik, Foo Jia-Nee, Askling Johan, Eloranta Sandra, Glimelius Ingrid, Liu Jianjun, Hjalgrim Henrik, Rosenquist Richard, Padyukov Leonid, Smedby Karin E
Abstract excerpt
Follicular lymphoma (FL) risk is strongly associated with germline genetic variation in human leukocyte antigen (HLA) class II. Cigarette smoking has been suggested to increase FL risk, primarily among women. We hypothesized that amino acids in HLA-antigen D-related β1 subunit (DRB1) interact with smoking in FL risk, as shown for rheumatoid arthritis. We analyzed 373 patients with FL and 818 controls from 2...
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