Article
A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
Scientific reports - 9 Dec 2019
Rivera Natalia V, Patasova Karina, Kullberg Susanna, Diaz-Gallo Lina Marcela, Iseda Tomoko, Bengtsson Camilla, Alfredsson Lars, Eklund Anders, Kockum Ingrid, Grunewald Johan, Padyukov Leonid
Abstract excerpt
The influence and effect of cigarette smoking in sarcoidosis is unclear. Here, we evaluated gene-environment interaction between multiple genetic variants including HLA genes and smoking in sarcoidosis defined by two clinical phenotypes, Löfgren's syndrome (LS) and patients without Löfgren's syndrome (non-LS). To quantify smoking effects in sarcoidosis, we performed a gene-environment interaction study in a...
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