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Article

HER2 signaling regulates HER2 localization and membrane retention

3 Apr 2017

Abstract excerpt

ErbB2/HER2/Neu is a receptor tyrosine kinase that is overexpressed in 25-30% of human breast cancers, usually associated with amplification of the ERBB2 gene. HER2 has no recognized ligands and heterodimers between HER2 and EGFR (ErbB1/HER1) or HER2 and ErbB3/HER3 are important in breast cancer. Unlike other ErbB family members, HER2 is resistant to internalization and degradation, and remains at the cell surface...

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PMID: 28369073
DOI: 10.1371/journal.pone.0174849

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