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Article

Enhanced HER2 internalization by clathrin-dependent endocytosis in non-small cell lung cancer positive for HER2 mutations.

British journal of cancer - 1 Oct 2025

Shimauchi Atsushi, Iwama Eiji, Ibusuki Ritsu, Tsutsumi Hirono, Shibahara Daisuke, Otsubo Kohei, Yoneshima Yasuto, Tanaka Kentaro, Okamoto Isamu

Abstract excerpt

BACKGROUND: HER2-targeted antibody-drug conjugates (ADCs) have shown marked efficacy for HER2 mutation-positive non-small cell lung cancer (NSCLC). The intracellular trafficking of mutant HER2 has remained to be fully elucidated, however. METHODS: HER2 dynamics were examined in cells expressing wild-type (WT) or mutant HER2 with the use of live cell imaging and an in situ proximity ligation assay. Proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40721523
DOI: 10.1038/s41416-025-03126-x
PMCID: PMC12479963

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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