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Article

ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.

Nature cell biology - 1 May 2017

Chatzinikolaou Georgia, Apostolou Zivkos, Aid-Pavlidis Tamara, Ioannidou Anna, Karakasilioti Ismene, Papadopoulos Giorgio L, Aivaliotis Michalis, Tsekrekou Maria, Strouboulis John, Kosteas Theodore, Garinis George A

Abstract excerpt

Inborn defects in DNA repair are associated with complex developmental disorders whose causal mechanisms are poorly understood. Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with the insulator binding protein CTCF, the cohesin subunits SMC1A and SMC3 and with MBD2; the factors co-localize with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28368372
DOI: 10.1038/ncb3499

Genes

CTCF
ERCC1
ATRX
MBD2
SMC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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