Article
Evolution of substrate specificity in a retained enzyme driven by gene loss.
eLife - 31 Mar 2017
Juárez-Vázquez Ana Lilia, Edirisinghe Janaka N, Verduzco-Castro Ernesto A, Michalska Karolina, Wu Chenggang, Noda-García Lianet, Babnigg Gyorgy, Endres Michael, Medina-Ruíz Sofía, Santoyo-Flores Julián, Carrillo-Tripp Mauricio, Ton-That Hung, Joachimiak Andrzej, Henry Christopher S, Barona-Gómez Francisco
Abstract excerpt
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that Actinomycetaceae genomes from human cavities are undergoing sizable reductions, including loss of L-histidine and L-tryptophan biosynthesis. We observe that the dual-substrate...
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