Article
Metabolic background determines the importance of NOS3 polymorphisms in restenosis after percutaneous coronary intervention: A study in patients with and without the metabolic syndrome.
Disease markers - 1 Jan 2009
Pons Douwe, Monraats Pascalle S, Zwinderman Aeilko H, de Maat Moniek P M, Doevendans Pieter A F M, de Winter Robbert J, Tio René A, Waltenberger Johannes, Jukema J Wouter
Abstract excerpt
Variation in the NOS3 gene has been related to the development of restenosis. The Glu298Asp polymorphism has previously been investigated for its effect on NO levels and the development of restenosis. However, the variability of findings gave rise to the hypothesis that the functional significance of this polymorphism may only become manifest under conditions of endothelial dysfunction. Since patients with the...
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