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Article

Identification of a Novel Somatic Mutation Leading to Allele Dropout for EGFR L858R Genotyping in Non-Small Cell Lung Cancer.

Molecular diagnosis & therapy - 1 Aug 2017

Costa Helio A, Neal Joel W, Bustamante Carlos D, Zehnder James L

Abstract excerpt

OBJECTIVE: While PCR-based genotyping methods abound in molecular testing for lung cancer therapy, these approaches may not provide the robust sensitivity to detect accurate genotypes in a variable cancer genomic background. METHODS: Here, we describe a study of a clinical tumor specimen containing a novel somatic single nucleotide variant that caused allele drop-out in EGFR L858R genotyping, resulting in a...

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Identifiers

PMID: 28357677
DOI: 10.1007/s40291-017-0275-y
PMCID: PMC5511778

Genes

EGFR

Variants

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