EGFR T790M Mutation in TKI-Naïve Clinical Samples: Frequency, Tissue Mosaicism, Predictive Value and Awareness on Artifacts.

doi:10.1159/000491441

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Article

EGFR T790M Mutation in TKI-Naïve Clinical Samples: Frequency, Tissue Mosaicism, Predictive Value and Awareness on Artifacts.

Oncology research and treatment - 1 Jan 2018

Lavdovskaia Elena D, Iyevleva Aglaya G, Sokolenko Anna P, Mitiushkina Natalia V, Preobrazhenskaya Elena V, Tiurin Vladislav I, Ivantsov Alexandr O, Bizin Ilya V, Stelmakh Liliya V, Moiseyenko Fedor V, Karaseva Nina A, Orlov Sergey V, Moiseyenko Vladimir M, Korzhenevskaya Marina A, Zaitsev Ivan A, Kozak Andrey R, Chistyakov Ivan V, Akopov Andrey L, Volkov Nikita M, Togo Alexandr V, Imyanitov Evgeny N

Abstract excerpt

BACKGROUND: This study evaluated the distribution of epidermal growth factor receptor (EGFR) T790M mutations in treatment-naïve tumor and normal samples obtained from cancer patients. METHODS: We utilized allele-specific PCR (AS-PCR), digital droplet PCR (ddPCR) and next generation sequencing (NGS) to detect EGFR T790M allele in several collections of tumor and normal human tissues. RESULTS: AS-PCR analysis of...

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PMID: 30145586
DOI: 10.1159/000491441

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