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Article

The Pitfalls of Companion Diagnostics: Evaluation of Discordant EGFR Mutation Results from a Clinical Laboratory and a Central Laboratory.

The Journal of molecular diagnostics : JMD - 1 May 2016

Turner Scott A, Peterson Jason D, Pettus Jason R, de Abreu Francine B, Amos Christopher I, Dragnev Konstantin H, Tsongalis Gregory J

Abstract excerpt

Accurate identification of somatic mutations in formalin-fixed, paraffin-embedded tumor tissue is required for enrollment into clinical trials for many novel targeted therapeutics, including trials requiring EGFR mutation status in non-small-cell lung carcinomas. Central clinical trial laboratories contracted to perform this analysis typically rely on US Food and Drug Administration-approved targeted assays to...

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Identifiers

PMID: 26923179
DOI: 10.1016/j.jmoldx.2015.12.004
PMCID: PMC5707184

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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