Article

Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome

2025-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate network activity, leading to seizure events. However, standard treatments to restore inhibition have limited efficacy, suggesting the existence of additional pathological mechanisms. Here, we use hiPSC-d...

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Literature Corpus work: c5befecf-d86c-57e9-9edc-eed06343f2e0
DOI: 10.1101/2025.10.03.680281

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