Article

Cortical Hyperexcitability Shapes Large-Scale Brain Dynamics and Behavioral Outcome in Angelman Syndrome

2026-03-24

Abstract excerpt

<h4>Background</h4> Angelman syndrome (AS) is a rare neurodevelopmental disorder with characteristic electroencephalographic abnormalities caused by loss of function of the maternally inherited UBE3A gene. Converging evidence suggests a disrupted excitation–inhibition (E/I) balance towards hyperexcitability. However, noninvasive approaches capable of characterizing intrinsic cortical excitability and its relation...

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Literature Corpus work: c3c0a92c-e3a9-52f0-8374-2ce8d8305c3d
DOI: 10.64898/2026.03.21.26348706

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