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Article

Epigenetic changes: the missing link.

Best practice & research. Clinical rheumatology - 1 Aug 2014

Kyburz Diego, Karouzakis Emmanuel, Ospelt Caroline

Abstract excerpt

The association of rheumatoid arthritis (RA) with a number of genetic risk loci is well established; however, only part of the risk to develop the disease is based on genetics. Environmental factors significantly contribute to the pathogenesis. A gene-environment interaction for smoking and certain major histocompatibility complex (MHC) class II alleles has been shown to promote anti-citrullinated protein...

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Identifiers

PMID: 25481551
DOI: 10.1016/j.berh.2014.10.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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