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Article

p53-targeted cancer pharmacotherapy: move towards small molecule compounds.

The Journal of pharmacy and pharmacology - 1 May 2011

Kim Soo-Hyun, Dass Crispin R

Abstract excerpt

OBJECTIVES: For the past three decades of research, p53 has been identified as one of the most targetable molecules for developing anticancer treatments. This tumour suppressor protein is involved in apoptosis, cell cycle arrest and senescence. A wide range of pharmaceutical drugs and radiotherapy treatments activate this protein and rely on p53 signalling for therapeutic outcome. Promising small molecular weight...

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Identifiers

PMID: 21492161
DOI: 10.1111/j.2042-7158.2010.01248.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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