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Article

IGF-1 receptor haploinsufficiency leads to age-dependent development of metabolic syndrome.

Biochemical and biophysical research communications - 13 May 2017

Thakur Sachin, Garg Neha, Zhang Ning, Hussey Sophie E, Musi Nicolas, Adamo Martin L

Abstract excerpt

Individuals born small for gestational age (SGA) are at a higher risk of developing the metabolic syndrome later in life. IGF-1 resistance has been reported in placentae from SGA births and mutations in the Igf1 receptor gene have been reported in several cohorts of SGA subjects. We have used the Igf1r heterozygous (Igf1r+/-) male mouse as a model to investigate the mechanisms by which Igf1r haploinsufficiency...

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Source

Identifiers

PMID: 28351623
DOI: 10.1016/j.bbrc.2017.03.129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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